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Article

Modulating calmodulin binding specificity through computational protein design.

Journal of molecular biology - 25 Oct 2002

Shifman Julia M, Mayo Stephen L

Abstract excerpt

We report the computational redesign of the protein-binding interface of calmodulin (CaM), a small, ubiquitous Ca(2+)-binding protein that is known to bind to and regulate a variety of functionally and structurally diverse proteins. The CaM binding interface was optimized to improve binding specificity towards one of its natural targets, smooth muscle myosin light chain kinase (smMLCK). The optimization was...

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Identifiers

PMID: 12381298
DOI: 10.1016/s0022-2836(02)00881-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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