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Article

Improving a natural CaMKII inhibitor by random and rational design.

PloS one - 1 Jan 2011

Coultrap Steven J, Bayer K Ulrich

Abstract excerpt

BACKGROUND: CaM-KIIN has evolved to inhibit stimulated and autonomous activity of the Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) efficiently, selectively, and potently (IC50 ∼100 nM). The CN class of peptides, derived from the inhibitory region of CaM-KIIN, provides powerful new tools to study CaMKII functions. The goal of this study was to identify the residues required for CaMKII inhibition,...

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Identifiers

PMID: 21984908
DOI: 10.1371/journal.pone.0025245
PMCID: PMC3184957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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