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Article

Arrhythmia-Associated Calmodulin E105A Mutation Alters the Binding Affinity of CaM to a Ryanodine Receptor 2 CaM-Binding Pocket.

International journal of molecular sciences - 26 Oct 2023

Thanassoulas Angelos, Theodoridou Maria, Barrak Laila, Riguene Emna, Alyaarabi Tamader, Elrayess Mohamed A, Lai F Anthony, Nomikos Michail

Abstract excerpt

Calmodulin (CaM) is a small, multifunctional calcium (Ca2+)-binding sensor that binds and regulates the open probability of cardiac ryanodine receptor 2 (RyR2) at both low and high cytosolic Ca2+ concentrations. Recent isothermal titration calorimetry (ITC) studies of a number of peptides that correspond to different regions of human RyR2 showed that two regions of human RyR2 (3584-3602aa and 4255-4271aa) bind...

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Identifiers

PMID: 37958614
DOI: 10.3390/ijms242115630
PMCID: PMC10649572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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