Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential phenotypes in mice with smooth muscle-specific heterozygous versus homozygous deletion of Stk11.

Scientific reports - 29 Dec 2025

Chen Haiping, Zhang Guifeng, Jiang Yangjing, Liang Min, Huang Yijie, Fang Liang, Chen Long, Xiao Danrui, Hu Yunwen, He Ben, Cai Zhaohua

Abstract excerpt

Liver kinase B1 (Lkb1), encoded by the serine/threonine kinase gene STK11, functions as a critical tumor suppressor associated with Peutz-Jeghers syndrome (PJS). Previous studies have shown that mesenchymal-specific deletion of Stk11 promotes the development of PJS-like polyps in murine models, highlighting its essential role in mesenchymal homeostasis. In this study, we generated tamoxifen-inducible...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinases
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homozygote

Share to Muscle, Smooth

Share to Myocytes, Smooth Muscle

Share to Myosin Heavy Chains

Share to Peutz-Jeghers Syndrome

Share to Protein Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 41461874
DOI: 10.1038/s41598-025-32712-5
PMCID: PMC12824263

Genes

STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential phenotypes in mice with smooth muscle-specific heterozygous versus homozygous deletion of Stk11.PMID 41461874Read ↗

Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formationSemantic proximity Read ↗

Intestinal LKB1 loss drives a pre-malignant program along the serrated cancer pathwaySemantic proximity Read ↗

Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.Semantic proximity Read ↗

Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway.Semantic proximity Read ↗

The tumor suppressor kinase LKB1: lessons from mouse modelsSemantic proximity Read ↗

Role of <i>Lkb1</i> , the causative gene of Peutz–Jegher's syndrome, in embryogenesis and polyposisSemantic proximity Read ↗

Stromal Liver Kinase B1 [STK11] Signaling Loss Induces Oviductal Adenomas and Endometrial Cancer by Activating Mammalian Target of Rapamycin Complex 1Semantic proximity Read ↗

Peutz-Jeghers syndrome without STK11 mutation may correlate with less severe clinical manifestations in Chinese patients.Semantic proximity Read ↗

STK11 (LKB1) missense somatic mutant isoforms promote tumor growth, motility and inflammationSemantic proximity Read ↗

LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies.Semantic proximity Read ↗

Relative frequency and morphology of cancers in STK11 mutation carriers.Semantic proximity Read ↗

Regulation of Ptbp1-controlled alternative splicing of pyruvate kinase muscle by liver kinase B1 governs vascular smooth muscle cell plasticity in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.