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Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria

1 Jan 2008

Abstract excerpt

Mycolactones are a family of highly related macrocyclic polyketides that exhibit immunosuppressive and cytotoxic properties. First discovered in 1999, they are the primary virulence factors produced by the environmental human pathogen Mycobacterium ulcerans, the causative agent of Buruli ulcer, and by some closely-related aquatic mycobacteria that cause disease in fish and frogs. Mycolactones are characterized by...

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PMID: 18497894
DOI: 10.1039/b803101k

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