Article
A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups.
Blood - 1 Jan 2009
Sulong Sarina, Moorman Anthony V, Irving Julie A E, Strefford Jonathan C, Konn Zoe J, Case Marian C, Minto Lynne, Barber Kerry E, Parker Helen, Wright Sarah L, Stewart Adam R M, Bailey Simon, Bown Nick P, Hall Andrew G, Harrison Christine J
Abstract excerpt
Inactivation of the tumor suppressor gene, CDKN2A, can occur by deletion, methylation, or mutation. We assessed the principal mode of inactivation in childhood acute lymphoblastic leukemia (ALL) and frequency in biologically relevant subgroups. Mutation or methylation was rare, whereas genomic deletion occurred in 21% of B-cell precursor ALL and 50% of T-ALL patients. Single nucleotide polymorphism arrays...
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