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CDKN2B downregulation and other genetic characteristics in T-acute lymphoblastic leukemia

1 Jan 2019

Abstract excerpt

We identified principal genetic alterations in 97.1% (99/102) of patients with T-acute lymphoblastic leukemia (T-ALL) using integrative genetic analyses, including massive parallel sequencing and multiplex ligation-dependent probe amplification (MLPA). A total of 133 mutations were identified in the following genes in descending order: NOTCH1 (66.7%), FBXW7 (19.6%), PHF6 (15.7%), RUNX1 (12.7%), NRAS (10.8%), and...

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PMID: 30635552
DOI: 10.1038/s12276-018-0195-x

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