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Article

Targeting NR1D1 in organ injury: challenges and prospects

10 Dec 2023

Abstract excerpt

Nuclear receptor subfamily 1, group D, member 1 (NR1D1, also known as REV-ERBα) belongs to the nuclear receptor (NR) family, and is a heme-binding component of the circadian clock that consolidates circadian oscillators. In addition to repressing the transcription of multiple clock genes associated with circadian rhythms, NR1D1 has a wide range of downstream target genes that are intimately involved in many...

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PMID: 38072952
DOI: 10.1186/s40779-023-00495-3

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