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Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway

30 Nov 2015

Abstract excerpt

The oxidation resistance gene 1 (OXR1) is crucial for protecting against oxidative stress; however, its molecular function is unknown. We employed RNA sequencing to examine the role of human OXR1 for genome wide transcription regulation. In total, in non-treated and hydrogen peroxide exposed HeLa cells, OXR1 depletion resulted in down-regulation of 554 genes and up-regulation of 253 genes. These differentially...

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PMID: 26616534
DOI: 10.1038/srep17409

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