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Article

Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance.

Nature communications - 19 Mar 2014

Tsang Chi Kwan, Liu Yuan, Thomas Janice, Zhang Yanjie, Zheng X F S

Abstract excerpt

Superoxide dismutase 1 (Sod1) has been known for nearly half a century for catalysis of superoxide to hydrogen peroxide. Here we report a new Sod1 function in oxidative signalling: in response to elevated endogenous and exogenous reactive oxygen species (ROS), Sod1 rapidly relocates into the nucleus, which is important for maintaining genomic stability. Interestingly, H2O2 is sufficient to promote Sod1 nuclear...

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PMID: 24647101
DOI: 10.1038/ncomms4446
PMCID: PMC4678626

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