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Article

Association of HPA axis genes with suicidal behaviour in schizophrenia.

Journal of psychopharmacology (Oxford, England) - 1 May 2010

De Luca V, Tharmalingam S, Zai C, Potapova N, Strauss J, Vincent J, Kennedy J L

Abstract excerpt

Family, adoption and twin studies show that genetics influences suicidal behaviour, but do not indicate specific susceptibility variants. Stress response is thought to be mediated by the corticotrophin-releasing hormone (CRH), which is known to be a regulator of the hypothalamic-pituitary-adrenal pathway (HPA). Alterations in HPA system have been related to impulsivity, aggression and suicidal behaviour, common...

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Share to CRF Receptor, Type 1
Share to Diagnostic and Statistical Manual of Mental Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18838498
DOI: 10.1177/0269881108097817

Genes

CRH
CRHBP
CRHR1
CRHR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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