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Article

Association study between the corticotropin-releasing hormone receptor 2 gene and suicidality in bipolar disorder.

European psychiatry : the journal of the Association of European Psychiatrists - 1 Jul 2007

De Luca Vincenzo, Tharmalingam Subi, Kennedy James L

Abstract excerpt

Family, adoption and twin studies show that genetics influences suicidal behavior, but does not indicate specific susceptibility variants. Stress response is thought to be mediated by the corticotrophin-releasing hormone (CRH), which is known to be a regulator of the hypothalamic-pituitary-adrenal pathway (HPA). Alterations in HPA system have been related to impulsivity, aggression and suicidal behaviour, that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17532191
DOI: 10.1016/j.eurpsy.2006.12.001

Genes

CRHR2
CRH
CRHR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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