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Article

Protein engineering of improved prolyl endopeptidases for celiac sprue therapy.

Protein engineering, design & selection : PEDS - 1 Dec 2008

Ehren Jennifer, Govindarajan Sridhar, Morón Belén, Minshull Jeremy, Khosla Chaitan

Abstract excerpt

Due to their unique ability to cleave immunotoxic gluten peptides endoproteolytically, prolyl endopeptidases (PEPs) are attractive oral therapeutic candidates for protecting celiac sprue patients from the toxic effects of dietary gluten. Enhancing the activity and stability of PEPs under gastric conditions (low pH, high pepsin concentration) is a challenge for protein engineers. Using a combination of sequence-...

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Identifiers

PMID: 18836204
DOI: 10.1093/protein/gzn050
PMCID: PMC2583057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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