Article

Specificity Enhancement of Glutenase Bga1903 Toward Celiac Disease-Eliciting Pro-immunogenic Peptides via Active-Site Modification

2023-11-25

Abstract excerpt

Celiac disease is an autoimmune disease triggered by oral ingestion of gluten, with certain gluten residues resistant to digestive tract enzymes. Within the duodenum, the remaining peptides incite immunogenic responses, including the generation of autoantibodies and inflammation, leading to irreversible damage. Our previous exploration unveiled a glutenase called Bga1903 derived from the Gram-negative bacterium Bu...

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Literature Corpus work: 564d9b0a-8a80-50c9-919e-3302a2a420a5
DOI: 10.20944/preprints202311.1601.v1

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