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Fermentation, purification, formulation, and pharmacological evaluation of a prolyl endopeptidase from <i>Myxococcus xanthus</i>: Implications for Celiac Sprue therapy

31 Aug 2005

Abstract excerpt

Celiac Sprue is a multi-factorial disease characterized by an inflammatory response to ingested wheat gluten and similar proteins in rye and barley. Proline-rich gluten peptides from wheat, rye, and barley are relatively resistant to gastrointestinal digestion, and therefore persist in the intestinal lumen to elicit immunopathology in genetically susceptible individuals. In this study, we characterize the in...

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PMID: 16136593
DOI: 10.1002/bit.20643

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