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Article

Association of ABCB1 genotypes with paclitaxel-mediated peripheral neuropathy and neutropenia.

European journal of cancer (Oxford, England : 1990) - 1 Nov 2006

Sissung Tristan M, Mross Klaus, Steinberg Seth M, Behringer Dirk, Figg William D, Sparreboom Alex, Mielke Stephan

Abstract excerpt

Here, we evaluated the relationships between ABCB1 (P-glycoprotein, MDR1) polymorphisms and paclitaxel (Taxol)-induced toxicity and pharmacokinetics. Twenty-six patients were assessable for pharmacogenetics and pharmacokinetics, 22 for neurotoxicity and 18 for myelotoxicity. Patients carrying two reference alleles for the ABCB1 3435C>T polymorphism trended toward a reduced risk to develop neuropathy as compared...

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Share to Antineoplastic Agents, Phytogenic
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Share to Neutropenia

Share to Organic Anion Transporters

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Share to Peripheral Nervous System Diseases

Share to Polymorphism, Genetic

Source

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Identifiers

PMID: 16950614
DOI: 10.1016/j.ejca.2006.06.017
PMCID: PMC1647318

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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