Article
HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer.
Oncogene - 30 Mar 2017
Stojanovic N, Hassan Z, Wirth M, Wenzel P, Beyer M, Schäfer C, Brand P, Kroemer A, Stauber R H, Schmid R M, Arlt A, Sellmer A, Mahboobi S, Rad R, Reichert M, Saur D, Krämer O H, Schneider G
Abstract excerpt
Mutation of p53 is a frequent genetic lesion in pancreatic cancer being an unmet clinical challenge. Mutants of p53 have lost the tumour-suppressive functions of wild type p53. In addition, p53 mutants exert tumour-promoting functions, qualifying them as important therapeutic targets. Here, we show that the class I histone deacetylases HDAC1 and HDAC2 contribute to maintain the expression of p53 mutants in human...
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