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Article

HDAC8 and STAT3 repress BMF gene activity in colon cancer cells

16 Oct 2014

Abstract excerpt

Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone acetylation in human colon cancer...

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Share to Epigenetics and DNA Methylation
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PMID: 25321483
DOI: 10.1038/cddis.2014.422

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