Article
Performance of mitochondrial DNA mutations detecting early stage cancer.
BMC cancer - 3 Oct 2008
Jakupciak John P, Maragh Samantha, Markowitz Maura E, Greenberg Alissa K, Hoque Mohammad O, Maitra Anirban, Barker Peter E, Wagner Paul D, Rom William N, Srivastava Sudhir, Sidransky David, O'Connell Catherine D
Abstract excerpt
BACKGROUND: Mutations in the mitochondrial genome (mtgenome) have been associated with cancer and many other disorders. These mutations can be point mutations or deletions, or admixtures (heteroplasmy). The detection of mtDNA mutations in body fluids using resequencing microarrays, which are more...
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