Article
Panel of prototypical recombinant infectious molecular clones resistant to nevirapine, efavirenz, etravirine, and rilpivirine.
Antimicrobial agents and chemotherapy - 1 Aug 2012
Balamane Maya, Varghese Vici, Melikian George L, Fessel W Jeffrey, Katzenstein David A, Shafer Robert W
Abstract excerpt
We created a panel of 10 representative multi-nonnucleoside reverse transcriptase inhibitor (NNRTI)-resistant recombinant infectious molecular HIV-1 clones to assist researchers studying NNRTI resistance or developing novel NNRTIs. The cloned viruses contain most of the major NNRTI resistance mutations and most of the significantly associated mutation pairs that we identified in two network analyses. Each virus...
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