Article
Transmitted drug resistance in the CFAR network of integrated clinical systems cohort: prevalence and effects on pre-therapy CD4 and viral load.
PloS one - 1 Jan 2011
Poon Art F Y, Aldous Jeannette L, Mathews W Christopher, Kitahata Mari, Kahn James S, Saag Michael S, Rodríguez Benigno, Boswell Stephen L, Frost Simon D W, Haubrich Richard H
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) genomes often carry one or more mutations associated with drug resistance upon transmission into a therapy-naïve individual. We assessed the prevalence and clinical significance of transmitted drug resistance (TDR) in chronically-infected therapy-naïve patients enrolled in a multi-center cohort in North America. Pre-therapy clinical significance was quantified by plasma...
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