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Article

Common human ANK2 variant confers in vivo arrhythmia phenotypes.

Heart rhythm - 1 Sept 2016

Musa Hassan, Murphy Nathaniel P, Curran Jerry, Higgins John D, Webb Tyler R, Makara Michael A, Wright Patrick, Lancione Peter J, Lubbers Ellen R, Healy Jane A, Smith Sakima A, Bennett Vann, Hund Thomas J, Kline Crystal F, Mohler Peter J

Abstract excerpt

BACKGROUND: Human ANK2 (ankyrin-B) loss-of-function variants are directly linked with arrhythmia phenotypes. However, in atypical non-ion channel arrhythmia genes such as ANK2 that lack the same degree of robust structure/function and clinical data, it may be more difficult to assign variant disease risk based simply on variant location, minor allele frequency, and/or predictive structural algorithms. The human...

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Source

Identifiers

PMID: 27298202
DOI: 10.1016/j.hrthm.2016.06.012

Genes

ANK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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