Article
Smarter clustering methods for SNP genotype calling.
Bioinformatics (Oxford, England) - 1 Dec 2008
Lin Yan, Tseng George C, Cheong Soo Yeon, Bean Lora J H, Sherman Stephanie L, Feingold Eleanor
Abstract excerpt
MOTIVATION: Most genotyping technologies for single nucleotide polymorphism (SNP) markers use standard clustering methods to 'call' the SNP genotypes. These methods are not always optimal in distinguishing the genotype clusters of a SNP because they do not take advantage of specific features of the genotype calling problem. In particular, when family data are available, pedigree information is ignored....
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