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Article

Rapid genotype refinement for whole-genome sequencing data using multi-variate normal distributions.

Bioinformatics (Oxford, England) - 1 Aug 2016

Arthur Rudy, O'Connell Jared, Schulz-Trieglaff Ole, Cox Anthony J

Abstract excerpt

MOTIVATION: Whole-genome low-coverage sequencing has been combined with linkage-disequilibrium (LD)-based genotype refinement to accurately and cost-effectively infer genotypes in large cohorts of individuals. Most genotype refinement methods are based on hidden Markov models, which are accurate but computationally expensive. We introduce an algorithm that models LD using a simple multivariate Gaussian...

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PMID: 27153730
DOI: 10.1093/bioinformatics/btw097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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