A computational method for genotype calling in family-based sequencing data.

doi:10.1186/s12859-016-0880-5

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Article

A computational method for genotype calling in family-based sequencing data.

BMC bioinformatics - 16 Jan 2016

Chang Lun-Ching, Li Bingshan, Fang Zhou, Vrieze Scott, McGue Matt, Iacono William G, Tseng George C, Chen Wei

Abstract excerpt

BACKGROUND: As sequencing technologies can help researchers detect common and rare variants across the human genome in many individuals, it is known that jointly calling genotypes across multiple individuals based on linkage disequilibrium (LD) can facilitate the analysis of low to modest coverage sequence data. However, genotype-calling methods for family-based sequence data, particularly for complex families...

Topics

Algorithms
Computational Biology
Computer Simulation
Databases, Genetic
Genome, Human
Genotyping Techniques
Haplotypes
Humans
Linkage Disequilibrium
Polymorphism, Single Nucleotide
Sequence Analysis, DNA

Source

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Identifiers

PMID: 26772743
DOI: 10.1186/s12859-016-0880-5
PMCID: PMC4715317

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