Article
SeqEM: an adaptive genotype-calling approach for next-generation sequencing studies.
Bioinformatics (Oxford, England) - 15 Nov 2010
Martin E R, Kinnamon D D, Schmidt M A, Powell E H, Zuchner S, Morris R W
Abstract excerpt
MOTIVATION: Next-generation sequencing presents several statistical challenges, with one of the most fundamental being determining an individual's genotype from multiple aligned short read sequences at a position. Some simple approaches for genotype calling apply fixed filters, such as calling a...
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