Incorporating genotyping uncertainty in haplotype inference for single-nucleotide polymorphisms.

Abstract excerpt

The accuracy of the vast amount of genotypic information generated by high-throughput genotyping technologies is crucial in haplotype analyses and linkage-disequilibrium mapping for complex diseases. To date, most automated programs lack quality measures for the allele calls; therefore, human interventions, which are both labor intensive and error prone, have to be performed. Here, we propose a novel genotype...

Topics

• Algorithms
• Computer Simulation
• Data Interpretation, Statistical
• Genetic Linkage
• Genotype
• Haplotypes
• Humans
• Polymorphism, Single-Stranded Conformational
• Sequence Analysis, DNA