Article
Decrease in excitatory neurons, astrocytes and proliferating progenitors in the cerebral cortex of mice lacking exon 3 from the Fgf2 gene.
BMC neuroscience - 30 Sept 2008
Chen Kesi, Ohkubo Yasushi, Shin Dana, Doetschman Thomas, Sanford L Philip, Li Hongqi, Vaccarino Flora M
Abstract excerpt
BACKGROUND: The Fgf2 gene is expressed in the brain neuroepithelium during embryonic development and in astroglial cells throughout life. Previous knockout studies suggested that FGF2 plays a role in the proliferation of neural progenitors in the embryonic cerebral cortex. These studies exclusively used knockout alleles lacking the Fgf2 exon 1. However, the description of putative alternative exons located...
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