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Article

Lipocalin-2 is increased in amyotrophic lateral sclerosis.

Muscle & nerve - 1 Aug 2020

Petrozziello Tiziana, Mills Alexandra N, Farhan Sali M K, Mueller Kaly A, Granucci Eric J, Glajch Kelly E, Chan James, Chew Sheena, Berry James D, Sadri-Vakili Ghazaleh

Abstract excerpt

BACKGROUND: The exact mechanisms underlying neuroinflammation and how they contribute to amyotrophic lateral sclerosis (ALS) pathogenesis remain unclear. One possibility is the secretion of neurotoxic factors, such as lipocalin-2 (LCN2), that lead to neuronal death. METHODS: LCN2 levels were measured in human postmortem tissue using Western blot, quantitative real time polymerase chain reaction, and...

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PMID: 32369618
DOI: 10.1002/mus.26911

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