Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Further studies on cold adapted variants of human influenza virus A/Krasnodar/101/59 (H2N2) with special reference to genetic stability of attenuation markers.

Acta virologica - 1 Aug 1991

Panzig B, Lisovskaya K B, Herrmann B, Klimov A, Döhner L

Abstract excerpt

A previously described cold adapted (ca) attenuated virus, K/25, derived from parent strain A/Krasnodar/101/59 (H2N2), was further modified by 35 additional passages in chick embryos at suboptimal temperature. The virus obtained had retained a distinct ts and ca phenotype and some other markers of attenuation but differed from formerly isolated ca variants by its higher genetic stability connected with an...

Topics

Animals
Chick Embryo
Cold Temperature
Cricetinae
Genes, Viral
Genetic Markers
Genetic Variation
Influenza A Virus, H2N2 Subtype
Influenza A virus
Phenotype
Viral Structural Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virulence

Source

Identifiers

PMID: 1686959

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1686959-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Further studies on cold adapted variants of human influenza virus A/Krasnodar/101/59 (H2N2) with special reference to genetic stability of attenuation markers.PMID 1686959Read ↗

[New cold-adapted donor strains for live influenza vaccine].Semantic proximity Read ↗

[The selection of cold-adapted variants of the influenza viruses H1N1 and H3N2 and their antigenic and genetic characteristics].Semantic proximity Read ↗

Molecular and biological changes in the cold-adapted "master strain" A/AA/6/60 (H2N2) influenza virus.Semantic proximity Read ↗

[Genetic stability of cold-adapted influenza viruses].Semantic proximity Read ↗

[MECHANISMS OF ATTENUATION OF COLD-ADAPTED STRAIN A/KRASNO- DAR/101/35/59 (H2N2)].Semantic proximity Read ↗

Sequence comparisons of A/AA/6/60 influenza viruses: mutations which may contribute to attenuation.Semantic proximity Read ↗

A genotype of modified vaccinia Ankara (MVA) that facilitates replication in suspension cultures in chemically defined medium.Semantic proximity Read ↗

Structural variation occurring in the hemagglutinin of influenza virus A/turkey/Oregon/71 during adaptation to different cell types.Semantic proximity Read ↗

Characterization of live influenza vaccine donor strain derived from cold-adaptation of X-31 virus.Semantic proximity Read ↗

Egg- or cell culture-derived hemagglutinin mutations impair virus stability and antigen content of inactivated influenza vaccines.Semantic proximity Read ↗

[Live cold-adapted influenza vaccine: state-of-the-art].Semantic proximity Read ↗

A serine-to-asparagine mutation at position 314 of H5N1 avian influenza virus NP is a temperature-sensitive mutation that interferes with nuclear localization of NP.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.