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Article

Further studies on cold adapted variants of human influenza virus A/Krasnodar/101/59 (H2N2) with special reference to genetic stability of attenuation markers.

Acta virologica - 1 Aug 1991

Panzig B, Lisovskaya K B, Herrmann B, Klimov A, Döhner L

Abstract excerpt

A previously described cold adapted (ca) attenuated virus, K/25, derived from parent strain A/Krasnodar/101/59 (H2N2), was further modified by 35 additional passages in chick embryos at suboptimal temperature. The virus obtained had retained a distinct ts and ca phenotype and some other markers of attenuation but differed from formerly isolated ca variants by its higher genetic stability connected with an...

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PMID: 1686959

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