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Article

Functional mutations in mouse norepinephrine transporter reduce sensitivity to cocaine inhibition.

Neuropharmacology - 1 Feb 2009

Wei Hua, Hill Erik R, Gu Howard H

Abstract excerpt

The transporters of dopamine, norepinephrine and serotonin are molecular targets of cocaine, amphetamine, and therapeutic antidepressants. The residues involved in binding these drugs are unknown. We have performed several rounds of random and site-directed mutagenesis in the mouse norepinephrine transporter and screened for mutants with altered sensitivity to cocaine inhibition of substrate uptake. We have...

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Identifiers

PMID: 18824182
DOI: 10.1016/j.neuropharm.2008.09.008
PMCID: PMC2666010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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