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Article

Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism.

Molecular pharmacology - 1 Apr 2002

Lin Zhicheng, Uhl George R

Abstract excerpt

Cocaine's blockade of dopamine reuptake by brain dopamine transporters (DAT) is a central feature of current understanding of cocaine reward and addiction. Empirical screening of small-molecule chemical libraries has thus far failed to provide successful cocaine blockers that allow dopamine reuptake in the presence of cocaine and provide cocaine "antagonism". We have approached this problem by assessing...

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Identifiers

PMID: 11901228
DOI: 10.1124/mol.61.4.885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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