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Article

Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference.

Proceedings of the National Academy of Sciences of the United States of America - 24 Apr 2001

Sora I, Hall F S, Andrews A M, Itokawa M, Li X F, Wei H B, Wichems C, Lesch K P, Murphy D L, Uhl G R

Abstract excerpt

Cocaine blocks uptake by neuronal plasma membrane transporters for dopamine (DAT), serotonin (SERT), and norepinephrine (NET). Cocaine reward/reinforcement has been linked to actions at DAT or to blockade of SERT. However, knockouts of neither DAT, SERT, or NET reduce cocaine reward/reinforcement...

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Share to Biogenic Monoamines
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conditioning, Psychological

Share to Dopamine Plasma Membrane Transport Proteins

Share to Receptor, Serotonin, 5-HT1B

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Source

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Identifiers

PMID: 11320258
DOI: 10.1073/pnas.091039298
PMCID: PMC33204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11320258-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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