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Article

Association of polymorphisms in CASP10 and CASP8 with FEV(1)/FVC and bronchial hyperresponsiveness in ethnically diverse asthmatics.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Nov 2008

Smith Alicia K, Lange Leslie A, Ampleford Elizabeth J, Meyers Deborah A, Bleecker Eugene R, Howard Timothy D

Abstract excerpt

BACKGROUND: Several chromosomal regions have been identified using family-based linkage analysis to contain genes contributing to the development of asthma and allergic disorders. One of these regions, chromosome 2q32-q33, contains a gene cluster containing CFLAR, CASP10 and CASP8. These genes regulate the extrinsic apoptosis pathway utilized by several types of immune and structural cells that have been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 18823309
DOI: 10.1111/j.1365-2222.2008.03095.x
PMCID: PMC3979622

Genes

CASP10
CASP8
CFLAR
FEV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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