Article
Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids.
The Journal of allergy and clinical immunology - 1 Mar 2014
Park Heung-Woo, Dahlin Amber, Tse Szeman, Duan Qing Ling, Schuemann Brooke, Martinez Fernando D, Peters Stephen P, Szefler Stanley J, Lima John J, Kubo Michiaki, Tamari Mayumi, Tantisira Kelan G
Abstract excerpt
BACKGROUND: To date, genome-wide association studies (GWASs) of inhaled corticosteroid (ICS) response in asthmatic patients have focused primarily on lung function and exacerbations. OBJECTIVE: We hypothesized that GWAS analysis could identify novel genetic markers predicting a symptomatic response to ICSs. METHODS: We analyzed differences in asthma symptoms in response to ICSs in 124 white children from the...
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