Article
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers.
Nature genetics - 1 May 2007
Sun Tong, Gao Yang, Tan Wen, Ma Sufang, Shi Yuankai, Yao Jiarui, Guo Yongli, Yang Ming, Zhang Xuemei, Zhang Qingrun, Zeng Changqing, Lin Dongxin
Abstract excerpt
Caspases are important in the life and death of immune cells and therefore influence immune surveillance of malignancies. We tested whether genetic variants in CASP8, CASP10 and CFLAR, three genes important for death receptor-induced cell killing residing in tandem order on chromosome 2q33, are associated with cancer susceptibility. Using a haplotype-tagging SNP approach, we identified a six-nucleotide deletion...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.