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Article

Spin-label EPR on alpha-synuclein reveals differences in the membrane binding affinity of the two antiparallel helices.

Chembiochem : a European journal of chemical biology - 13 Oct 2008

Drescher Malte, Godschalk Frans, Veldhuis Gertjan, van Rooijen Bart D, Subramaniam Vinod, Huber Martina

Abstract excerpt

The putative function of the Parkinson's disease-related protein alpha-Synuclein (alphaS) is thought to involve membrane binding. Therefore, the interaction of alphaS with membranes composed of zwitterionic (POPC) and anionic (POPG) lipids was investigated through the mobility of spin labels attached to the protein. Differently labelled variants of alphaS were produced, containing a spin label at positions 9, 18...

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Identifiers

PMID: 18821550
DOI: 10.1002/cbic.200800238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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