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Article

Production of Prnp-/- goats by gene targeting in adult fibroblasts.

Transgenic research - 1 Apr 2009

Zhu Caihong, Li Bei, Yu Guohua, Chen Jianquan, Yu Huiqing, Chen Juan, Xu Xujun, Wu Youbing, Zhang Aimin, Cheng Guoxiang

Abstract excerpt

Homozygous mice devoid of functional Prnp are resistant to scrapie and prion propagation, but heterozygous mice for Prnp disruption still suffer from prion disease and prion deposition. We have previously generated heterozygous cloned goats with one allele of Prnp functional disruption. To obtain goats with both alleles of Prnp be disrupted which would be resistant to scrapie completely, a second-round gene...

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Identifiers

PMID: 18821027
DOI: 10.1007/s11248-008-9220-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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