Article

CRISPR/Cas9-editing of PRNP in Alpine goats.

2024-11-15

Abstract excerpt

<title>Abstract</title> <p>Misfolding of the cellular PrP (PrP<sup>c</sup>) protein causes prion disease leading to neurodegenerative disorders in numerous mammalian species including goats. Lack of PrP<sup>c</sup> induces complete resistance to prion disease. The aim of this work was to engineered Alpine goats carrying knockout (KO) alleles of <italic>PRNP</italic>, the PrP<sup>c</sup>-encoding gene, using CRISP...

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Literature Corpus work: fea344e8-c1a0-54b1-9fb6-037c0838102b
DOI: 10.21203/rs.3.rs-5173836/v1

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