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Article

A novel promoterless gene targeting vector to efficiently disrupt PRNP gene in cattle.

Journal of biotechnology - 20 Feb 2013

Wang Shaohua, Zhang Kun, Ding Fangrong, Zhao Rui, Li Song, Li Rong, Xu Lingling, Song Chi, Dai Yunping, Li Ning

Abstract excerpt

The PRNP gene encodes a cellular protein named prion, whose misfolded form has been implicated in a number of neuropathic diseases in mammals such as the Bovine Spongiform Encephalopathy (BSE) in cattle. BSE has brought devastating impact on the world economy and human health. Recently, several g...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23201560
DOI: 10.1016/j.jbiotec.2012.10.018

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23201560-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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