Article
Sequential targeting of the genes encoding immunoglobulin-mu and prion protein in cattle.
Nature genetics - 1 Jul 2004
Kuroiwa Yoshimi, Kasinathan Poothappillai, Matsushita Hiroaki, Sathiyaselan Janaki, Sullivan Eddie J, Kakitani Makoto, Tomizuka Kazuma, Ishida Isao, Robl James M
Abstract excerpt
Gene targeting is accomplished using embryonic stem cells in the mouse but has been successful, only using primary somatic cells followed by embryonic cloning, in other species. Gene targeting in somatic cells versus embryonic stem cells is a challenge; consequently, there are few reported successes and none include the targeting of transcriptionally silent genes or double targeting to produce homozygotes. Here,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.