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Article

Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis.

Nature clinical practice. Rheumatology - 1 Oct 2008

Corr Maripat

Abstract excerpt

Osteoarthritis (OA) is a progressively degenerative joint condition that is influenced by various metabolic and structural factors. The canonical Wnt-frizzled-beta-catenin pathway has been implicated in the pathogenesis of OA. Products of the Wnt, frizzled, secreted frizzled-related protein (sFRP), Dickkopf and LDL-receptor-related protein gene families have crucial roles in the development and maintenance of...

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PMID: 18820702
DOI: 10.1038/ncprheum0904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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