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Article

Gene-gene interactions of the Wnt/β-catenin signaling pathway in knee osteoarthritis.

Molecular biology reports - 1 Oct 2018

Fernández-Torres Javier, Zamudio-Cuevas Yessica, López-Reyes Alberto, Garrido-Rodríguez Daniela, Martínez-Flores Karina, Lozada Carlos Alberto, Muñóz-Valle José Francisco, Oregon-Romero Edith, Martínez-Nava Gabriela Angélica

Abstract excerpt

This study was designed to investigate whether genetic polymorphisms of the Wnt/β-catenin signaling pathway and its interactions are involved in the development of knee osteoarthritis (KOA). Patients with KOA (n = 131) and healthy individuals (n = 190) with different ancestry from two Mexican populations (Mexico City and Guadalajara City) were analyzed. Twenty-five SNPs from thirteen genes (WISP1, DKK1, SOST,...

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Source

Identifiers

PMID: 30083988
DOI: 10.1007/s11033-018-4260-2

Genes

FRZB
FMN2
SOST
LRP6
ADAMTS5
DKK1
GDF5
LRP1
LRP4
LRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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