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Article

Sumoylation of LAP1 is involved in the HDAC4-mediated repression of COX-2 transcription.

Nucleic acids research - 1 Nov 2008

Wang Wen-Ling, Lee Yi-Chao, Yang Wen-Ming, Chang Wen-Chang, Wang Ju-Ming

Abstract excerpt

CEBPB, one of the CEBP family members, is a crucial regulator of gene expression during innate immunity, inflammatory responses and adipogenesis. In this study, the EGF-induced increase of CEBPB mRNA is shown to be coincident with the decrease of COX-2 mRNA. We identified that all of the individual CEBPB isoforms, LAP1, LAP2 and LIP, attenuate EGF-induced COX-2 promoter activity. Although increased sumoylation of...

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Share to Protein Isoforms
Share to CCAAT-Enhancer-Binding Protein-beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclooxygenase 2

Share to Epidermal Growth Factor

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Source

Open in PubMed Open full text

Identifiers

PMID: 18820298
DOI: 10.1093/nar/gkn607
PMCID: PMC2577330

Genes

HDAC4
EGF
SUMO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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