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Article

Essential Roles of COUP-TFII in Leydig Cell Differentiation and Male Fertility

25 Sept 2008

Abstract excerpt

Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII; also known as NR2F2), is an orphan nuclear receptor of the steroid/thyroid hormone receptor superfamily. COUP-TFII-null mice die during the early embryonic development due to angiogenesis and cardiovascular defects. To circumvent the early embryonic lethality and investigate the physiological function of COUP-TFII, we knocked out COUP-TFII...

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PMID: 18818749
DOI: 10.1371/journal.pone.0003285

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Essential Roles of COUP-TFII in Leydig Cell Differentiation and Male FertilityPMID 18818749Read ↗

Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiencySemantic proximity Read ↗

Chicken ovalbumin upstream promoter transcription factor type II interacts and functionally cooperates with GATA4 to regulate anti‐Müllerian hormone receptor type 2 transcription in mouse MA‐10 Leydig cellsSemantic proximity Read ↗

NR2F2 is required in the embryonic testis for Fetal Leydig Cell developmentSemantic proximity Read ↗

Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actionsSemantic proximity Read ↗

Evidence for NR2F2/COUP-TFII involvement in human testis development.Semantic proximity Read ↗

The Chicken Ovalbumin Upstream Promoter-Transcription Factor II Negatively Regulates the Transactivation of Androgen Receptor in Prostate Cancer CellsSemantic proximity Read ↗

COUP-TFII Mediates Progesterone Regulation of Uterine Implantation by Controlling ER ActivitySemantic proximity Read ↗

COUP-TFII regulates early bipotential gonad signaling and commitment to ovarian progenitorsSemantic proximity Read ↗

Evidence for <i>NR2F2</i> /COUP-TFII involvement in human testis developmentSemantic proximity Read ↗

Loss of Function of the Nuclear Receptor NR2F2, Encoding COUP-TF2, Causes Testis Development and Cardiac Defects in 46,XX Children.Semantic proximity Read ↗

Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in miceSemantic proximity Read ↗

Steroidogenic Factor 1 Differentially Regulates Fetal and Adult Leydig Cell Development in Male Mice1Semantic proximity Read ↗

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