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Article

Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiency

2 Apr 2007

Abstract excerpt

COUP-TFII (NR2F2), chicken ovalbumin upstream promoter-transcription factor II, is an orphan nuclear receptor of the steroid/thyroid hormone receptor superfamily. The Coup-tfII-null mutant mice die during the early embryonic development because of angiogenesis and heart defects. To analyze the physiological function of COUP-TFII during organogenesis, we used the cre/loxP system to conditionally inactivate...

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PMID: 17404209
DOI: 10.1073/pnas.0702039104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiencyPMID 17404209Read ↗

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Essential Roles of COUP-TFII in Leydig Cell Differentiation and Male FertilitySemantic proximity Read ↗

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Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFIISemantic proximity Read ↗

Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid–Activated ReceptorSemantic proximity Read ↗

Loss of Function of the Nuclear Receptor NR2F2, Encoding COUP-TF2, Causes Testis Development and Cardiac Defects in 46,XX Children.Semantic proximity Read ↗

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