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Article

The Chicken Ovalbumin Upstream Promoter-Transcription Factor II Negatively Regulates the Transactivation of Androgen Receptor in Prostate Cancer Cells

7 Nov 2012

Abstract excerpt

Androgen receptor (AR) is involved in the development and progression of prostate cancers. However, the mechanisms by which this occurs remain incompletely understood. In previous reports, chicken ovalbumin upstream promoter-transcription factor II (COUP-TF II) has been suggested to play a role in the development of cancers. In the present study, we explored a putative role of COUP-TF II in prostate cancers by...

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PMID: 23145053
DOI: 10.1371/journal.pone.0049026

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The Chicken Ovalbumin Upstream Promoter-Transcription Factor II Negatively Regulates the Transactivation of Androgen Receptor in Prostate Cancer CellsPMID 23145053Read ↗

Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actionsSemantic proximity Read ↗

Chicken ovalbumin upstream promoter transcription factor type II interacts and functionally cooperates with GATA4 to regulate anti‐Müllerian hormone receptor type 2 transcription in mouse MA‐10 Leydig cellsSemantic proximity Read ↗

Essential Roles of COUP-TFII in Leydig Cell Differentiation and Male FertilitySemantic proximity Read ↗

Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatmentSemantic proximity Read ↗

Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Dimers Bind to Different GGTCA Response Elements, Allowing COUP-TF To Repress Hormonal Induction of the Vitamin D<sub>3</sub>, Thyroid Hormone, and Retinoic Acid ReceptorsSemantic proximity Read ↗

Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid–Activated ReceptorSemantic proximity Read ↗

Ubc9 interacts with chicken ovalbumin upstream promoter-transcription factor I and represses receptor-dependent transcription.Semantic proximity Read ↗

The COUP-TFII variant lacking a DNA-binding domain inhibits the activation of the Cyp7a1 promoter through physical interaction with COUP-TFII.Semantic proximity Read ↗

Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor.Semantic proximity Read ↗

The orphan nuclear receptors COUP-TFI and COUP-TFII regulate expression of the gonadotropin LHβ gene.Semantic proximity Read ↗

COUP-TFII Mediates Progesterone Regulation of Uterine Implantation by Controlling ER ActivitySemantic proximity Read ↗

Cloning and Characterization of Androgen Receptor Coactivator, ARA55, in Human ProstateSemantic proximity Read ↗

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