A paucimorphic variant in the HMG-CoA reductase gene is associated with lipid-lowering response to statin treatment in diabetes: a GoDARTS study.

doi:10.1097/FPC.0b013e3283106071

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Article

A paucimorphic variant in the HMG-CoA reductase gene is associated with lipid-lowering response to statin treatment in diabetes: a GoDARTS study.

Pharmacogenetics and genomics - 1 Dec 2008

Donnelly Louise A, Doney Alex S F, Dannfald Jennifer, Whitley Adrian L, Lang Chim C, Morris Andrew D, Donnan Peter T, Palmer Colin N A

Abstract excerpt

BACKGROUND: Considerable interindividual variation exists in cholesterol-lowering response to 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) inhibitors (statins). HMGCR catalyzes the rate-limiting step in cholesterol biosynthesis, and also plays a significant role in cholesterol homeostasis. We evaluated the association of a single nucleotide polymorphism (rs17238540) in the HMGCR gene with...

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PMID: 18815589
DOI: 10.1097/FPC.0b013e3283106071

Genes

HMGCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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