Article
Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells.
Cancer research - 1 Dec 2003
Edinger Aimee L, Linardic Corinne M, Chiang Gary G, Thompson Craig B, Abraham Robert T
Abstract excerpt
Rapamycin and its analogues have shown promising anticancer activities in preclinical and clinical studies. However, the mechanism whereby rapamycin inhibits signaling through the mammalian target of rapamycin (mTOR) remains poorly understood. Here, we show that the FKBP12/rapamycin complex is an essentially irreversible inhibitor of mTOR kinase activity in vitro. However, we observe no suppression of mTOR...
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