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Article

Evaluation of mTOR function by a gain-of-function approach.

Cell cycle (Georgetown, Tex.) - 15 Feb 2009

Ohne Yoichiro, Takahara Terunao, Maeda Tatsuya

Abstract excerpt

The mammalian target of rapamycin (mTOR), a member of the phosphoinositide 3-kinase related kinase (PIKK) family, plays a central role in the regulation of cell growth. The cellular function of mTOR has been proposed based solely on loss-of-function analyses using the specific inhibitor rapamycin or RNAi-mediated knockdown. There have been recent reports of mTOR mutants with enhanced activity that were isolated...

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Identifiers

PMID: 19182527
DOI: 10.4161/cc.8.4.7660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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